New & Noteworthy Publications
The CVG is committed to increasing awareness of current genomics research in our community. Listed below are the latest noteworthy publications from CVG member labs. We hope this will be a helpful way to stay informed of the exciting genomics work that is happening on our campus.
Director's Highlights Fall 2020
Le HH, Johnson EL.
Cell Host Microbe. 2020 Jul 8;28(1):3-5. doi: 10.1016/j.chom.2020.06.012. PMID: 32645352.
This article from Dr. Liz Johnson's lab (DNS) offers an important commentary on recent research describing the role of gut microbiota in mediating the effects of ketogenic diets on the immune system. Liz is one of the newest members of the CVG and we're excited about her interdisciplinary research program at the interface of genomics, molecular nutrition, lipid biology, and host-microbe interactions.
Shi H, Shi Q, Grodner B, Lenz JS, Zipfel WR, Brito IL, De Vlaminck I.
Nature. 2020 Dec;588(7839):676-681. doi: 10.1038/s41586-020-2983-4. Epub 2020 Dec 2. PMID: 33268897.
This exciting study introduces a new technology, referred to as high-phylogenetic-resolution microbiome by fluorescence in situ hybridization (HiPR-FISH), for studying the spatial distribution of microbial communities at single-cell resolution. The microbiomes of the murine gut and human oral plaque are investigated closely. This work represents a collaboration among the Zipfel, De Vlaminck, and Brito labs (BME).
High resolution single cell transcriptomics reveals heterogeneity of self-renewing hair follicle stem cells.
Chovatiya G, Ghuwalewala S, Walter LD , Cosgrove BD, Tumbar T.
Exp Dermatol. 2020 Dec 15. doi: 10.1111/exd.14262. Epub ahead of print. PMID: 33319418.
In this collaborative work between the Cosgrove (BME) and Tumbar (MBG) labs, the authors leverage single-cell approaches to define the heterogeneity of hair follicle stem cells (HFSC) during self-renewal. This work lays the foundation for the investigation of different functions associated with the distinct HFSC populations. Congrats to 2021 CVG Scholar Sangeeta Ghuwalewala and 2021 Developmental Genomics T32 fellow Lauren Walter, who are both co-authors on the study.
Paternal deprivation impairs social behavior putatively via epigenetic modification to lateral septum vasopressin receptor.
Kelly AM, Ong JY, Witmer RA, Ophir AG
Science Advances 2020 Sep 2;6(36):eabb9116. doi: 10.1126/sciadv.abb9116.
This interesting study from the Ophir lab (Psychology) links changes in DNA methylation to the sex-specific effects of parental care on the social behavior of prairie vole offspring. Alex Ophir is one of the newest members of the CVG and his group's research interests at the interface of neuroethology and epigenomics is a wonderful addition to our community.
Tippens ND, Liang J, Leung AK, Wierbowski SD, Ozer A, Booth JG, Lis JT, Yu H.
Nat Genet. 2020 Oct;52(10):1067-1075. doi: 10.1038/s41588-020-0686-2. Epub 2020 Sep 21. PMID: 32958950; PMCID: PMC7541647.
In this comprehensive study, from the Lis (MBG) and Yu (Computational Biology) labs, the authors show that GRO-cap signal offers higher resolution for defining active enhancers than traditional approaches that make use of histone marks. Notably, the study also suggests a functional role for Pol II recruitment at enhancers. Congratulations to the study's leading authors Nate Tippens, a previous Developmental Genomics T32 fellow, and Jin Liang.
Cyclin N-Terminal Domain-Containing-1 Coordinates Meiotic Crossover Formation with Cell-Cycle Progression in a Cyclin-Independent Manner.
Gray S, Santiago ER, Chappie JS, Cohen PE.
Cell Rep. 2020 Jul 7;32(1):107858. doi: 10.1016/j.celrep.2020.107858. PMID: 32640224; PMCID: PMC7341696.
In this study, the Cohen lab (BMS) identifies in mouse testis a short-form of the protein CNTD1, which they reveal has a role in facilitating crossover formation during the cell cycle. Interestingly, this function is not mediated by interactions with cyclin-dependent kinases. These findings have important implications for the timing and control of prophase I in the male mouse. Furthermore, this alternative non-cyclin function of CNTD1 suggests that this protein may function in different ways to regulate crossing over across eukaryotes.